Article

Osteoclasts contribute to early development of chronic inflammation by promoting dysregulated hematopoiesis and myeloid skewing

2020-12-11

Abstract excerpt

<h4>ABSTRACT</h4> Increased myelopoiesis is a hallmark of many chronic inflammatory diseases. However, the mechanisms involved in the myeloid skewing of hematopoiesis upon inflammation are still incompletely understood. Here, we identify an unexpected role of bone-resorbing osteoclasts in promoting hematopoietic stem cell (HSC) proliferation and differentiation towards myeloipoiesis in the early phases of chronic...

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Literature Corpus work: 1cfee5f0-8efd-5687-8c35-7d3c6c79464a
DOI: 10.1101/2020.12.09.418137

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