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Article

Viral Activation of Heparanase Drives Pathogenesis of Herpes Simplex Virus-1

1 Jul 2017

Abstract excerpt

Herpes simplex virus-1 (HSV-1) causes lifelong recurrent pathologies without a cure. How infection by HSV-1 triggers disease processes, especially in the immune-privileged avascular human cornea, remains a major unresolved puzzle. It has been speculated that a cornea-resident molecule must tip the balance in favor of pro-inflammatory and pro-angiogenic conditions observed with herpetic, as well as non-herpetic,...

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PMID: 28700944
DOI: 10.1016/j.celrep.2017.06.041

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