The NF–Y splicing signature controls hybrid EMT and ECM-related pathways to promote aggressiveness of colon cancer

Abstract excerpt

Aberrant splicing events are associated with colorectal cancer (CRC) and provide new opportunities for tumor diagnosis and treatment. The expression of the splice variants of NF-YA, the DNA binding subunit of the transcription factor NF–Y, is deregulated in multiple cancer types compared to healthy tissues. NF–YAs and NF–YAl isoforms differ in the transactivation domain, which may result in distinct...

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