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Single-Cell Analysis of <i>NF1</i> -Expressing and <i>NF1</i> -Deficient Schwann and Fibroblast Cells Reveals Divergent Neurofibroma Programs

2025-09-28

Abstract excerpt

Neurofibromatosis type 1 (NF1) is an inherited tumor predisposition syndrome characterized by the development of benign peripheral nerve sheath tumors, most commonly cutaneous neurofibromas (cNFs) and plexiform neurofibromas (pNFs). Although both tumor types arise from Schwann cells and share NF1 loss as a genetic driver, they differ markedly in growth behavior, microenvironmental context, and clinical outcomes,...

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Literature Corpus work
9701ca21-ed0a-5a0d-be4f-ef371d4eef10
DOI
10.1101/2025.09.26.677858
Open publication

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Single-Cell Analysis of <i>NF1</i> -Expressing and <i>NF1</i> -Deficient Schwann and Fibroblast Cells Reveals Divergent Neurofibroma ProgramsDOI 10.1101/2025.09.26.677858
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