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Article

Genetics, Functions, and Clinical Impact of Presenilin-1 (PSEN1) Gene.

International journal of molecular sciences - 19 Sept 2022

Bagaria Jaya, Bagyinszky Eva, An Seong Soo A

Abstract excerpt

Presenilin-1 (PSEN1) has been verified as an important causative factor for early onset Alzheimer's disease (EOAD). PSEN1 is a part of γ-secretase, and in addition to amyloid precursor protein (APP) cleavage, it can also affect other processes, such as Notch signaling, β-cadherin processing, and calcium metabolism. Several motifs and residues have been identified in PSEN1, which may play a significant role in...

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Identifiers

PMID: 36142879
DOI: 10.3390/ijms231810970
PMCID: PMC9504248

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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