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Article

The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.

PLoS genetics - 1 Jul 2015

Frank Amanda K, Tran Duy C, Qu Roy W, Stohr Bradley A, Segal David J, Xu Lifeng

Abstract excerpt

Dyskeratosis Congenita (DC) is a heritable multi-system disorder caused by abnormally short telomeres. Clinically diagnosed by the mucocutaneous symptoms, DC patients are at high risk for bone marrow failure, pulmonary fibrosis, and multiple types of cancers. We have recapitulated the most common DC-causing mutation in the shelterin component TIN2 by introducing a TIN2-R282H mutation into cultured...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 26230315
DOI: 10.1371/journal.pgen.1005410
PMCID: PMC4521702

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The Shelterin TIN2 Subunit Mediates Recruitment of Telomerase to Telomeres.PMID 26230315Read ↗

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