Article
A role for heterochromatin protein 1γ at human telomeres.
Genes & development - 1 Sept 2011
Canudas Silvia, Houghtaling Benjamin R, Bhanot Monica, Sasa Ghadir, Savage Sharon A, Bertuch Alison A, Smith Susan
Abstract excerpt
Human telomere function is mediated by shelterin, a six-subunit complex that is required for telomere replication, protection, and cohesion. TIN2, the central component of shelterin, has binding sites to three subunits: TRF1, TRF2, and TPP1. Here we identify a fourth partner, heterochromatin protein 1γ (HP1γ), that binds to a conserved canonical HP1-binding motif, PXVXL, in the C-terminal domain of TIN2. We show...
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