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Acute depletion of telomerase components DKC1 and NOP10 induces oxidative stress and disrupts ribosomal biogenesis via NPM1 and activation of the P53 pathway.

Biochimica et biophysica acta. Molecular cell research - 1 Dec 2020

Ibáñez-Cabellos José Santiago, Seco-Cervera Marta, Picher-Latorre Carmen, Pérez-Machado Gisselle, García-Giménez José Luis, Pallardó Federico V

Abstract excerpt

Mutations in DKC1, NOP10, and TINF2 genes, coding for proteins in telomerase and shelterin complexes, are responsible for diverse diseases known as telomeropathies and ribosomopathies, including dyskeratosis congenita (DC, ORPHA 1775). These genes contribute to the DC phenotype through mechanisms that are not completely understood. We previously demonstrated in models of DC that oxidative stress is an early and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 32910990
DOI: 10.1016/j.bbamcr.2020.118845

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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