Article

Translating GWAS Findings to Inform Drug Repositioning Strategies for COVID-19 Treatment

2023-10-19

Abstract excerpt

<title>Abstract</title> <p>We developed a computational framework that integrates Genome-Wide Association Studies (GWAS) and post-GWAS analyses, designed to facilitate drug repurposing for COVID-19 treatment. The comprehensive approach combines transcriptomic-wide associations, polygenic priority scoring, 3D genomics, viral-host protein-protein interactions, and small-molecule docking. Through GWAS, we identified...

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Literature Corpus work: 01931351-5376-51f8-a016-ce4166056805
DOI: 10.21203/rs.3.rs-3443080/v1

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