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Article

Phox2B mutations and the Delta-Notch pathway in neuroblastoma.

Cancer letters - 18 Oct 2005

van Limpt Vera, Chan Alvin, Schramm Alexander, Eggert Angelika, Versteeg Rogier

Abstract excerpt

We recently identified six neuroblastoma patients with constitutional or tumor-specific mutations in the homeobox gene Phox2B. Phox2B controls part of the differentiation program of the sympathetic nervous system (SNS). Mice with a homozygous inactivation of Phox2B fail in the proper differentiation of the chromaffin lineage of the SNS. Phox2B regulates HASH1 which can control expression of genes of the...

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PMID: 16084642
DOI: 10.1016/j.canlet.2005.02.050

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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