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Article

KDM2B/FBXL10 targets c-Fos for ubiquitylation and degradation in response to mitogenic stimulation.

Oncogene - 11 Aug 2016

Han X-R, Zha Z, Yuan H-X, Feng X, Xia Y-K, Lei Q-Y, Guan K-L, Xiong Y

Abstract excerpt

KDM2B (also known as FBXL10) controls stem cell self-renewal, somatic cell reprogramming and senescence, and tumorigenesis. KDM2B contains multiple functional domains, including a JmjC domain that catalyzes H3K36 demethylation and a CxxC zinc-finger that recognizes CpG islands and recruits the polycomb repressive complex 1. Here, we report that KDM2B, via its F-box domain, functions as a subunit of the CUL1-RING...

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Topics

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Share to Epidermal Growth Factor
Share to F-Box Proteins
Share to Jumonji Domain-Containing Histone Demethylases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogens

Share to Proteolysis

Share to Proto-Oncogene Proteins c-fos

Share to Ubiquitin-Protein Ligases

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Source

Open in PubMed Open full text

Identifiers

PMID: 26725323
DOI: 10.1038/onc.2015.482
PMCID: PMC4931990

Genes

CUL1
EGF
SKP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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