Article

Ultra-high sensitivity mass spectrometry quantifies single-cell proteome changes upon perturbation

2020-12-22

Abstract excerpt

Single-cell technologies are revolutionizing biology but are today mainly limited to imaging and deep sequencing 1–3 . However, proteins are the main drivers of cellular function and in-depth characterization of individual cells by mass spectrometry (MS)-based proteomics would thus be highly valuable and complementary 4,5 . Chemical labeling-based single-cell approaches introduce hundreds of cells into the MS, b...

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Literature Corpus work: 793d5110-82a6-56c1-bc3e-4018faaa0dcd
DOI: 10.1101/2020.12.22.423933

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