Article

Differential G protein activation by fusion proteins between the human δ-opioid receptor and Gᵢ₁α/G₀₁α proteins

2001-01-01

Abstract excerpt

Assessment of the functional activities of agonists acting on the human 6-opioid receptor (hDOR) which couples to G proteins of the Gi/Goalpha class usually involves the measurement of adenylyl cyclase (AC) activity. To assess the relative capacitiy of the hDOR to activate closely related G proteins, fusion proteins were constructed in which the a subunits of either Gi1 or Go1, containing point mutations to render...

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Literature Corpus work: 7925fac8-a5bf-567c-8d48-6fbd5cf4b606
DOI: 10.5525/gla.thesis.72487

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