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Article

ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2.

Cellular signalling - 1 Dec 2009

Rankovic Marija, Jacob Lea, Rankovic Vladan, Brandenburg Lars-Ove, Schröder Helmut, Höllt Volker, Koch Thomas

Abstract excerpt

Endocytosis of the mu-opioid receptor (MOPr) has been shown to play a protective role against the development of tolerance to opioid drugs by facilitating receptor reactivation and recycling. It has been further demonstrated, that the opioid-mediated and ADP-ribosylation factor (ARF)-dependent activation of phospholipase D2 (PLD2) is a prerequisite for MOPr endocytosis. In this study, we investigated which...

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Source

Identifiers

PMID: 19666113
DOI: 10.1016/j.cellsig.2009.07.014

Genes

ARF6
PLD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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ADP-ribosylation factor 6 regulates mu-opioid receptor trafficking and signaling via activation of phospholipase D2.PMID 19666113Read ↗

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