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Article

Mechanisms and function of autophagy in intestinal disease.

Autophagy - 1 Jan 2018

Lassen Kara G, Xavier Ramnik J

Abstract excerpt

The discovery of numerous genetic variants in the human genome that are associated with inflammatory bowel disease (IBD) has revealed critical pathways that play important roles in intestinal homeostasis. These genetic studies have identified a critical role for macroautophagy/autophagy and more recently, lysosomal function, in maintaining the intestinal barrier and mucosal homeostasis. This review highlights...

Topics

Animals
Autophagy
Autophagy-Related Proteins
Crohn Disease
Cytokines
Genetic Predisposition to Disease
Humans
Inflammatory Bowel Diseases
Intestinal Mucosa
Lysosomes
Mice
Reactive Oxygen Species

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29130415
DOI: 10.1080/15548627.2017.1389358
PMCID: PMC5902220

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