Article

Linking Altered Neuronal and Synaptic Properties to Nicotinic Receptor Alpha5 Subunit Gene Dysfunction: A Translational Investigation in Rat mPFC and Human Cortical Layer 6

2024-04-12

Abstract excerpt

<h4>Background</h4> Genetic variation in the α5 nicotinic acetylcholine receptor (nAChR) subunit of mice results in behavioral deficits linked to the prefrontal cortex (PFC). A Single Nucleotide Polymorphisms (SNP) in CHRNA5 imparts a partial loss of function to the α5 subunit-containing (α5*) nAChRs and have been demonstrated to be associated with psychiatric disorders in humans, including schizophrenia, nicotin...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 78b4debc-8076-5160-b588-1313548c979d
DOI: 10.1101/2024.04.12.589167

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Linking Altered Neuronal and Synaptic Properties to Nicotinic Receptor Alpha5 Subunit Gene Dysfunction: A Translational Investigation in Rat mPFC and Human Cortical Layer 6DOI 10.1101/2024.04.12.589167Read

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia.Semantic proximity Read

Alterations in alpha5* nicotinic acetylcholine receptors result in midbrain- and hippocampus-dependent behavioural and neural impairments.Semantic proximity Read

α6-Containing nicotinic acetylcholine receptors in midbrain dopamine neurons are poised to govern dopamine-mediated behaviors and synaptic plasticity.Semantic proximity Read

5-HT(1A) receptors direct the orientation of plasticity in layer 5 pyramidal neurons of the mouse prefrontal cortex.Semantic proximity Read

Alterations of cortical pyramidal neurons in mice lacking high-affinity nicotinic receptors.Semantic proximity Read

Transcriptome-Inspired Spiking Simulations Uncover Human-Specific Prefrontal Dynamics and Provide a Mechanistic Platform for Species-Appropriate Disease ModelingSemantic proximity Read

Targeting alpha7 nicotinic acetylcholine receptors in the treatment of schizophrenia.Semantic proximity Read

Increased nicotine response in iPSC-derived human neurons carrying the CHRNA5 N398 allele.Semantic proximity Read

The nicotinic receptor alpha5 coding polymorphism rs16969968 as a major target in disease: Functional dissection and remaining challenges.Semantic proximity Read

Distinct Chrna5 mutations link excessive alcohol use to types I/II vulnerability profiles and IPN GABAergic neurons.Semantic proximity Read

Molecular and pharmacological investigation of alpha 7 nicotinic acetylcholine receptors in human induced pluripotent stem cell-derived dentate gyrus granule cellsSemantic proximity Read

Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.Semantic proximity Read