Article

Transcriptome-Inspired Spiking Simulations Uncover Human-Specific Prefrontal Dynamics and Provide a Mechanistic Platform for Species-Appropriate Disease Modeling

2026-08-03

Abstract excerpt

Whole-brain transcriptomic atlases are now widely available, yet computational neural models are almost exclusively parameterized from rodent data and used to infer human brain function, an extrapolation whose cost remains unquantified. To address this, we constructed a biophysically detailed, conductance-based Hodgkin–Huxley spiking microcircuit of a five-population prefrontal network, where every ion-channel, re...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 69358b95-4030-572d-8bf8-fa40fc5342d8
DOI: 10.64898/2026.08.02.741879

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptome-Inspired Spiking Simulations Uncover Human-Specific Prefrontal Dynamics and Provide a Mechanistic Platform for Species-Appropriate Disease ModelingDOI 10.64898/2026.08.02.741879Read

Modeling reveals human-rodent differences in h-current kinetics influencing resonance in cortical layer 5 neuronsSemantic proximity Read

Hyperpolarization-activated cation channels shape the spiking frequency preference of human cortical layer 5 pyramidal neuronsSemantic proximity Read

HCN channels reveal conserved and divergent physiology in supragranular pyramidal neurons in primate speciesSemantic proximity Read

Cellular and Synaptic Diversity of Layer 2-3 Pyramidal Neurons in Human IndividualsSemantic proximity Read

Simple models of quantitative firing phenotypes in hippocampal neurons: Comprehensive coverage of intrinsic diversity.Semantic proximity Read

Morphoelectric Diversity and Specialization of Neuronal Cell Types in the Primate StriatumSemantic proximity Read

Multimodal analyses reveal genes driving electrophysiological maturation of neurons in the primate prefrontal cortexSemantic proximity Read

An update to Hippocampome.org by integrating single-cell phenotypes with circuit function in vivo.Semantic proximity Read

Cholinergic heterogeneity facilitates synchronization and information flow in a whole-brain modelSemantic proximity Read

Somatic HCN channels augment and speed up GABAergic basket cell input-output function in human neocortexSemantic proximity Read

Quantitative firing pattern phenotyping of hippocampal neuron types.Semantic proximity Read

Functional Cell-Type Identification in Neuronal Networks Using High-Density Microelectrode ArraysSemantic proximity Read