Inactivation of <scp><i>RB1</i></scp>, <scp><i>CDKN2A</i></scp>, and <scp><i>TP53</i></scp> have distinct effects on genomic stability at side‐by‐side comparison in karyotypically normal cells

Abstract excerpt

Chromosomal instability is a common feature in malignant tumors. Previous studies have indicated that inactivation of the classical tumor suppressor genes RB1, CDKN2A, and TP53 may contribute to chromosomal aberrations in cancer by disrupting different aspects of the cell cycle and DNA damage checkpoint machinery. We performed a side-by-side comparison of how inactivation of each of these genes affected...

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