Article

Widespread DNA off-targeting confounds studies of RNA chromatin occupancy

2025-11-11

Abstract excerpt

The importance of long noncoding RNA (lncRNA) functions is recognized across biological systems, but their modes of action remain poorly understood. One mechanism proposed to be particularly common is gene expression regulation via recruitment to specific genomic regions. Several high-throughput sequencing methods were developed for studying the genome-wide chromatin occupancy of lncRNAs, including ChIRP-seq, CHAR...

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Literature Corpus work: e21922cb-2857-55c9-81b8-9708d328303c
DOI: 10.1101/2025.11.11.687850

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