Article

Human Papillomavirus Infection Blunts STING Signaling and Alters Downstream Response

2025-11-06

Abstract excerpt

The cGAS/STING pathway is an important innate immune pathway that senses and responds to foreign DNA or damaged host DNA. cGAS recognizes DNA and generates the second messenger cGAMP which activates STING. STING then creates a platform for IRF3 to be phosphorylated before pIRF3 induces a type I interferon response resulting in transcription of anti-viral genes. We examined how HPV18 infection modulates cGAS/STING...

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Literature Corpus work: c0c16ec6-e759-55e8-9d3f-da9fcfc355d6
DOI: 10.1101/2025.11.06.686957

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