Article

Evolutionary and Functional Lessons from Human-Specific Amino-Acid Substitution Matrices

2020-09-21

Abstract excerpt

<title>Abstract</title> <p>The characterization of human genetic variation in coding regions is fundamental to the understanding of protein function, structure and evolution. Amino-acid (AA) substitution matrices encapsulate the stochastic nature of such proteomic variation and are widely used in studying protein families and evolutionary processes. The conventional substitution matrices, namely BLOSUM and PAM, w...

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Literature Corpus work: f5d9d916-b139-5652-9a85-ad5395b90dcc
DOI: 10.21203/rs.3.rs-63387/v1

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