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Article

Structural and functional restraints on the occurrence of single amino acid variations in human proteins.

PloS one - 12 Feb 2010

Gong Sungsam, Blundell Tom L

Abstract excerpt

Human genetic variation is the incarnation of diverse evolutionary history, which reflects both selectively advantageous and selectively neutral change. In this study, we catalogue structural and functional features of proteins that restrain genetic variation leading to single amino acid substitu...

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Identifiers

PMID: 20169194
DOI: 10.1371/journal.pone.0009186
PMCID: PMC2820541

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20169194-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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