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Article

Predicting Amino Acid Substitution Probabilities Using Single Nucleotide Polymorphisms.

Genetics - 1 Oct 2017

Rizzato Francesca, Rodriguez Alex, Biarnés Xevi, Laio Alessandro

Abstract excerpt

Fast genome sequencing offers invaluable opportunities for building updated and improved models of protein sequence evolution. We here show that Single Nucleotide Polymorphisms (SNPs) can be used to build a model capable of predicting the probability of substitution between amino acids in variants of the same protein in different species. The model is based on a substitution matrix inferred from the frequency of...

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Share to Amino Acid Substitution
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Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Genetic

Share to Polymorphism, Single Nucleotide

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Share to Sequence Alignment

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Identifiers

PMID: 28754661
DOI: 10.1534/genetics.117.300078
PMCID: PMC5629329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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