Article

Amyloid β-peptide impacts on glucose regulation are dependent on apolipoprotein E genotype

2022-06-26

Abstract excerpt

The apolipoprotein E gene ( APOE ) constitutes the greatest genetic risk factor for Alzheimer’s disease, wherein the ε4 allele confers a dramatically elevated risk compared to the more common ε3 allele. Biological mechanisms that differ across these alleles have been explored in mouse models wherein the murine Apoe gene has undergone targeted replacement with sequences encoding human ApoE3 or -4 (ApoE-TR mice)....

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Literature Corpus work: 785c85da-90e6-58e0-99ba-1d8781aad192
DOI: 10.1101/2022.06.22.497222

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