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Article

Amyloid β-Peptide Effects on Glucose Regulation Are Dependent on Apolipoprotein E Genotype.

eNeuro - 1 Apr 2023

Sung Jin Hee, Ou Yang, Barger Steven W

Abstract excerpt

The apolipoprotein E gene (APOE) confers the greatest genetic risk factor for Alzheimer's disease (AD), wherein the ε4 allele confers an elevated risk compared with the ε3 allele. Biological mechanisms that differ across these alleles have been explored in mouse models wherein the murine Apoe gene has undergone targeted replacement with sequences encoding human ApoE3 or ApoE4 (ApoE-TR mice). Such models have...

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Identifiers

PMID: 37163733
DOI: 10.1523/ENEURO.0376-22.2023
PMCID: PMC10135078

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