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Article

PLK2 disrupts autophagic flux to promote SNCA/α-synuclein pathology

8 Jan 2025

Abstract excerpt

The aggregation and transmission of SNCA/α-synuclein (synuclein, alpha) is a hallmark pathology of Parkinson disease (PD). PLK2 (polo like kinase 2) is an evolutionarily conserved serine/threonine kinase that is more abundant in the brains of all family members, is highly expressed in PD, and is linked to SNCA deposition. However, in addition to its role in phosphorylating SNCA, the role of PLK2 in PD and the...

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PMID: 39773002
DOI: 10.1080/15548627.2024.2448914

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