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Article

Forward genetic screen in zebrafish identifies new fungal regulators that limit host-protective Candida-innate immune interaction.

mBio - 14 May 2025

Blair Bailey A, Bragdon Emma, Dhillon Gursimran, Baker Nnamdi, Stasiak Lena, Muthig Mya, Miramon Pedro, Lorenz Michael C, Wheeler Robert T

Abstract excerpt

Candida is one of the most frequent causes of bloodstream infections, and our first line of defense against these invasive infections is the innate immune system. The early immune response is critical in controlling Candida albicans infection, but C. albicans has several strategies to evade host immune attack. Phagocytosis of C. albicans blocks hyphal growth, limiting host damage and virulence, but how C....

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 40172223
DOI: 10.1128/mbio.00529-25
PMCID: PMC12077120

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