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Article

Global analysis of fungal morphology exposes mechanisms of host cell escape

31 Mar 2015

Abstract excerpt

Developmental transitions between single-cell yeast and multicellular filaments underpin virulence of diverse fungal pathogens. For the leading human fungal pathogen Candida albicans, filamentation is thought to be required for immune cell escape via induction of an inflammatory programmed cell death. Here we perform a genome-scale analysis of C. albicans morphogenesis and identify 102 negative morphogenetic...

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PMID: 25824284
DOI: 10.1038/ncomms7741

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