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9-cis-Retinoic Acid Improves Disease Modelling in iPSC-Derived Liver Organoids

26 Jun 2025

Abstract excerpt

Liver fibrosis majorly impacts global health, necessitating the development of in vitro models to study disease mechanisms and develop drug therapies. Relevant models should at least include hepatocytes and hepatic stellate cells (HSCs) and ideally use three-dimensional cultures to mimic in vivo conditions. Induced pluripotent stem cells (iPSCs) allow for patient-specific liver modelling, but current models based...

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PMID: 40643504
DOI: 10.3390/cells14130983

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