Article

Identifying cancer pathway dysregulations using differential causal effects

2021-05-21

Abstract excerpt

Signaling pathways control cellular behavior. Dysregulated pathways, for example due to mutations that cause genes and proteins to be expressed abnormally, can lead to diseases, such as cancer. We introduce a novel computational approach, called Differential Causal Effects ( dce ), which compares normal to cancerous cells using the statistical framework of causality. The method allows to detect individual edges i...

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Literature Corpus work: 782e74e5-243c-5fea-823b-5b5b7bb96bc0
DOI: 10.1101/2021.05.20.444965

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