Article

Revealing the impact of genomic alterations on cancer cell signaling with a partially transparent deep learning model

2020-05-30

Abstract excerpt

Cancer is a disease of aberrant cellular signaling and tumor-specific aberrations in signaling systems determine the aggressiveness of a cancer and response to therapy. Identifying such abnormal signaling pathways causing a patient’s cancer would enable more patient-specific and effective treatments. We interpret the cellular signaling system as a causal graphical model, where it is known that genomic alterations...

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Literature Corpus work: 8737c702-1d55-52e4-92c0-6a9a212f4acc
DOI: 10.1101/2020.05.29.113605

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