Article

Perturbation-based gene regulatory network inference to unravel oncogenic mechanisms

2019-08-15

Abstract excerpt

The gene regulatory network (GRN) of human cells encodes mechanisms to ensure proper functioning. However, if this GRN is dysregulated, the cell may enter into a disease state such as cancer. Understanding the GRN as a system can therefore help identify novel mechanisms underlying disease, which can lead to new therapies. Reliable inference of GRNs is however still a major challenge in systems biology. To deduce r...

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Literature Corpus work: cd4c94c0-1a55-592f-808c-b9185739b4e2
DOI: 10.1101/735514

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