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Article

Causal Network Models for Predicting Compound Targets and Driving Pathways in Cancer.

Journal of biomolecular screening - 1 Jun 2014

Jaeger Savina, Min Junxia, Nigsch Florian, Camargo Miguel, Hutz Janna, Cornett Allen, Cleaver Stephen, Buckler Alan, Jenkins Jeremy L

Abstract excerpt

Gene-expression data are often used to infer pathways regulating transcriptional responses. For example, differentially expressed genes (DEGs) induced by compound treatment can help characterize hits from phenotypic screens, either by correlation with known drug signatures or by pathway enrichment. Pathway enrichment is, however, typically computed with DEGs rather than "upstream" nodes that are potentially...

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PMID: 24518063
DOI: 10.1177/1087057114522690

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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