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Genetic Epidemiological Pipeline Identifies Candidate Markers of Clozapine-Induced Metabolic Dysfunction Revealing Potential Avenues for Precision Clozapine Prescription

2026-03-19

Abstract excerpt

0. Clozapine is the gold-standard for treatment-resistant schizophrenia despite its severe metabolic complications, including metabolic syndrome (MetS) and type 2 diabetes (T2D) risk. A better understanding of the genetic factors influencing clozapine pharmacokinetics and their relationship to metabolic risk could help inform precision medicine approaches to clozapine prescribing. Using a series of genetic-epidemi...

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Literature Corpus work
7826d4e4-faf7-5f12-ada5-660b61f8fa26
DOI
10.64898/2026.03.17.26348301
Open publication

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Genetic Epidemiological Pipeline Identifies Candidate Markers of Clozapine-Induced Metabolic Dysfunction Revealing Potential Avenues for Precision Clozapine PrescriptionDOI 10.64898/2026.03.17.26348301
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