Article

Pharmaceutical Repurposing Strategies for Metabolic Disorders: Insights from Mendelian Randomization Studies

2024-03-30

Abstract excerpt

Metabolic disorders (MDs) are a group of medical conditions that impact the metabolism. These complex processes may have common characteristics among various diseases, thereby suggesting the potential of drug repurposing. Employing Mendelian Randomization (MR), we constructed a causal network between 2,478 targetable drug-gene expressions (eQTLs) and 30 broadly reported metabolic disorders. Our study identified 49...

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Literature Corpus work: 1cf3f506-7db0-519f-b9b2-c6a262f2bc61
DOI: 10.1101/2024.03.29.24305070

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