Article
Genome Wide Association Study (GWAS) Identifies Novel Genetic Loci for Second-Generation Antipsychotics (SGA)-Induced Metabolic Syndrome (MetS).
Clinical and translational science - 1 Apr 2025
El Rouby Nihal, Owusu-Obeng Aniwaa, Preuss Michael H, Lee Simon, Shi Mingjian, Nadukuru Rajiv, Van Driest Sara L, Mosley Jonathan D, DelBello Melissa
Abstract excerpt
Second-generation antipsychotics (SGA) are widely used for treating psychiatric disorders; however, their use is associated with an increased risk of metabolic syndrome (MetS). To identify common genetic associations of SGA-induced metabolic syndrome (SGA-MetS), we conducted a genome-wide association study (GWAS) in a diverse patient population within the BioVU and BioMe electronic health records (EHRs)-linked...
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