Article
Complement 3 and metabolic syndrome induced by clozapine: a cross-sectional study and retrospective cohort analysis.
The pharmacogenomics journal - 1 Jan 2017
Zhang C, Zhang Y, Cai J, Chen M, Song L
Abstract excerpt
Metabolic syndrome (MetS) is considered to be an adverse effect of long-term treatment with atypical antipsychotics, particularly clozapine. There is strong evidence that the activation of inflammatory pathways interferes with normal metabolism and contributes to the development of MetS. C3, which is an inflammation molecule, has been reported to be associated with MetS. Because C3 is a heritable trait, we...
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