Article

Omicron Coronavirus Variant: pH-Dependent Electrostatic Potentials and Energy of Association of S-Protein to ACE2 Receptor

2022-08-26

Abstract excerpt

The association of S-protein of SARS-CoV-2 beta-coronavirus to ACE2 receptors of the human epithelial cells determines its contagiousness and pathogenicity. We compute pH-dependent electric potential on the surface of the interacting globular proteins (ACE2 receptor, S-protein, its S1-subunit, and their complex) and alteration of Gibbs free energy at association of the wild-type strain and omicron variant. The iso...

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Literature Corpus work: cbcf46d7-aaf6-51dc-992e-81e8791d6af5
DOI: 10.2139/ssrn.4192637

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