Article
A database for curating the associations between killer cell immunoglobulin-like receptors and diseases in worldwide populations.
Database : the journal of biological databases and curation - 1 Jan 2013
Takeshita Louise Y C, Gonzalez-Galarza Faviel F, dos Santos Eduardo J M, Maia Maria Helena T, Rahman Mushome M, Zain Syed M S, Middleton Derek, Jones Andrew R
Abstract excerpt
The killer cell immunoglobulin-like receptors (KIR) play a fundamental role in the innate immune system, through their interactions with human leucocyte antigen (HLA) molecules, leading to the modulation of activity in natural killer (NK) cells, mainly related to killing pathogen-infected cells. KIR genes are hugely polymorphic both in the number of genes an individual carries and in the number of alleles...
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