Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Purine-mediated signalling triggers eye development.

Nature - 25 Oct 2007

Massé Karine, Bhamra Surinder, Eason Robert, Dale Nicholas, Jones Elizabeth A

Abstract excerpt

A conserved network of eye field transcription factors (EFTFs) underlies the development of the eye in vertebrates and invertebrates. To direct eye development, Pax6, a key gene in this network, interacts with genes encoding other EFTFs such as Rx1 and Six3 (refs 4-6). However, the mechanisms that control expression of the EFTFs remain unclear. Here we show that purine-mediated signalling triggers both EFTF...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Diphosphate
Share to Choristoma
Share to Eye

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Paired Box Transcription Factors

Share to PAX6 Transcription Factor

Share to Purines

Share to Receptors, Purinergic P2

Share to Xenopus Proteins

Source

Identifiers

PMID: 17960245
DOI: 10.1038/nature06189

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Purine-mediated signalling triggers eye development.PMID 17960245Read ↗

Pax6 induces ectopic eyes in a vertebrate.Semantic proximity Read ↗

Drosophila CtBP regulates proliferation and differentiation of eye precursors and complexes with Eyeless, Dachshund, Dan, and Danr during eye and antennal development.Semantic proximity Read ↗

Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients.Semantic proximity Read ↗

Restoration of functional PAX6 in aniridia patient iPSC-derived ocular tissue models using repurposed nonsense suppression drugsSemantic proximity Read ↗

Regulation of vertebrate eye development by Rx genes.Semantic proximity Read ↗

Anterior eye development and ocular mesenchyme: new insights from mouse models and human diseases.Semantic proximity Read ↗

CD73 Controls Ocular Adenosine Levels and Protects Retina from Light-Induced PhototoxicitySemantic proximity Read ↗

Genetic network of the eye in Platyhelminthes: expression and functional analysis of some players during planarian regeneration.Semantic proximity Read ↗

Functional dissection of eyes absent reveals new modes of regulation within the retinal determination gene network.Semantic proximity Read ↗

CRISPR/Cas9-mediated mutation reveals Pax6 is essential for development of the compound eye in Decapoda Exopalaemon carinicauda.Semantic proximity Read ↗

Generation of eye field/optic vesicle-like structures from human embryonic stem cells under two-dimensional and chemically defined conditions.Semantic proximity Read ↗

Pax proteins and eye development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.