Article

Development of a physiological insulin resistance model in human stem cell-derived adipocytes

2022-02-22

Abstract excerpt

Adipocytes are key regulatory cells of human metabolism, and their dysfunction in insulin signaling is central to metabolic diseases such as type II diabetes mellitus (T2D). However, the progression of insulin resistance that leads to T2D is still poorly understood. This limited understanding is due, in part, to the dearth of suitable models of insulin signaling in human adipocytes. Traditionally, in vitro adipocy...

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Literature Corpus work: 77b375da-c99e-5b61-9cd7-94e910479f55
DOI: 10.1101/2022.02.22.481495

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