Article

<i>In vitro</i> model of human subcutaneous adipocyte spheroids for studying mitochondrial dysfunction and mitochondria activating compounds

2025-04-19

Abstract excerpt

<h4>SUMMARY</h4> Mitochondrial abnormalities drive subcutaneous white adipose tissue dysfunction in obesity, leading to metabolic complications. A key challenge in obesity research is the lack of in vitro models to study human adipocyte mitochondria. Here, we establish a human subcutaneous adipocyte spheroid model to characterize mitochondrial metabolism under obesity-relevant conditions and drug exposure. Huma...

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Literature Corpus work: b7791235-8047-502b-901e-fd3fe1a06801
DOI: 10.1101/2025.04.16.649074

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