Article

Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brain

2020-12-02

Abstract excerpt

TREM2 is an immunoglobulin-like receptor expressed by certain myeloid cells, such as macrophages, dendritic cells, osteoclasts and microglia. In the brain, TREM2 plays an important role in the immune function of microglia, and its dysfunction is linked to various neurodegenerative conditions in humans. Ablation of TREM2 or its adaptor protein TYROBP causes Polycystic Lipo-Membranous Osteodysplasia with Sclerosing...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 77a25bc9-2081-5bb2-ad5e-d445a555e390
DOI: 10.1101/2020.11.30.404897

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Novel TREM2 splicing isoform that lacks the V-set immunoglobulin domain is abundant in the human brainDOI 10.1101/2020.11.30.404897Read

An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brainSemantic proximity Read

TREM2 brain transcript-specific studies in AD and TREM2 mutation carriersSemantic proximity Read

TREM2 variants that cause early dementia and increase Alzheimer's disease risk affect gene splicing.Semantic proximity Read

Contributions of triggering-receptor-expressed-on-myeloid-cells-2 to neurological diseasesSemantic proximity Read

Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease.Semantic proximity Read

The role of TREM2 in Alzheimer's disease and other neurodegenerative disorders.Semantic proximity Read

Mutations in TREM2 lead to pure early-onset dementia without bone cysts.Semantic proximity Read

Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult miceSemantic proximity Read

Mutations in two genes encoding different subunits of a receptor signaling complex result in an identical disease phenotype.Semantic proximity Read

CELF2 regulates the species-specific alternative splicing of TREM2Semantic proximity Read

TREM2 in CNS homeostasis and neurodegenerative disease.Semantic proximity Read

Loss of Trem2 in microglia leads to widespread disruption of cell co-expression networks in mouse brainSemantic proximity Read