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Article

CELF2 regulates the species-specific alternative splicing of TREM2

22 Oct 2020

Abstract excerpt

Genetic variations of TREM2 have been implicated as a risk factor of Alzheimer's disease (AD). Recent studies suggest that the loss of TREM2 function compromises microglial responses to the accumulation of amyloid beta. Previously, we found that exon 3 of TREM2 is an alternative exon whose skipping leads to a reduction in full-length TREM2 protein by inducing nonsense-mediated mRNA decay. Here, we aimed to...

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PMID: 33093587
DOI: 10.1038/s41598-020-75057-x

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