Article

An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brain

2021-11-23

Abstract excerpt

<h4>Background</h4> Genetic variants in TREM2 are strongly associated with Alzheimer’s Disease (AD) risk but alternative splicing in TREM2 transcripts has not been comprehensively described. <h4>Objective</h4> Recognizing that alternative splice variants can result in reduced gene expression and/or altered function, we sought to fully characterize splice variation in TREM2 . <h4>Methods</h4> Human blood an...

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Literature Corpus work: 155808c1-9a4c-56b6-a035-9c4124bd8da0
DOI: 10.1101/2021.11.23.469712

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