Article

ZIF-1-mediated degradation of endogenous and heterologous zinc finger proteins in the <i>C. elegans</i> germ line

2023-07-10

Abstract excerpt

Rapid and conditional protein depletion is the gold standard genetic tool for deciphering the molecular basis of developmental processes. Previously, we showed that by conditionally expressing the E3 ligase substrate adaptor ZIF-1 in Caenorhabditis elegans somatic cells, proteins tagged with the first CCCH Zn finger (ZF1) domain from the germline regulator PIE-1 degrade rapidly, resulting in loss-of-function phen...

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Literature Corpus work: 777d58f7-af2b-5c06-84a6-9aed6b0996b3
DOI: 10.1101/2023.07.10.548405

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