Article
A conserved C. elegans zinc finger homeodomain protein, ZFH-2, is continuously required for the structural integrity and function of the alimentary tract and gonad.
Development (Cambridge, England) - 1 Apr 2026
Sussfeld Antoine, Vidal Berta, Sural Surojit, Merritt Daniel M, Aguilar G Robert, Ramadan Yasmin H, Hobert Oliver
Abstract excerpt
An unusually large transcription factor arose at the base of bilaterian evolution through domain shuffling that recombined many copies of two distinct DNA-binding domains, C2H2-type zinc fingers and homeodomains. The function of this deeply conserved type of protein remains poorly characterized. We describe here the complete and complex expression pattern of its sole Caenorhabditis elegans representative, ZFH-2,...
Topics
- Animals
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Zinc Fingers
- Homeodomain Proteins
- Gene Expression Regulation, Developmental
- Gonads
- Gastrointestinal Tract
- Amino Acid Sequence
- Transcription Factors
- Mutation