Article
pos-1 encodes a cytoplasmic zinc-finger protein essential for germline specification in C. elegans.
Development (Cambridge, England) - 1 Jan 1999
Tabara H, Hill R J, Mello C C, Priess J R, Kohara Y
Abstract excerpt
Germ cells arise during early C. elegans embryogenesis from an invariant sequence of asymmetric divisions that separate germ cell precursors from somatic precursors. We show that maternal-effect lethal mutations in the gene pos-1 cause germ cell precursors to inappropriately adopt somatic cell fa...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Blastomeres
- Caenorhabditis elegans
- Caenorhabditis elegans Proteins
- Cytoplasm
- Embryo, Nonmammalian
- Gene Expression Regulation, Developmental
- Germ Cells
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- RNA-Binding Proteins
- Sodium Channels
- Stem Cells
- Transcription, Genetic
- Zinc Fingers