Article

Principles governing A-to-I RNA editing in the breast cancer transcriptome

2014-12-16

Abstract excerpt

<h4> ABSTRACT </h4> A-to-I editing substitutes inosines for adenosines at specific positions in mRNAs and can substantially alter a cell’s transcriptome. Currently, little is known about how RNA editing operates in cancer. Transcriptome analysis of 68 normal and cancerous breast tissues revealed that the editing enzyme ADAR acts uniformly, on the same loci, across tissues. Controlled ADAR expression experiments...

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Literature Corpus work: 8798b5b8-71a0-5e8c-aa3d-68b4bb0eba19
DOI: 10.1101/012849

Open publication

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