Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

doi:10.1002/jbmr.4323

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Article

Germline Saturation Mutagenesis Induces Skeletal Phenotypes in Mice.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Aug 2021

Rios Jonathan J, Denton Kristin, Russell Jamie, Kozlitina Julia, Ferreira Carlos R, Lewanda Amy F, Mayfield Joshua E, Moresco Eva, Ludwig Sara, Tang Miao, Li Xiaohong, Lyon Stephen, Khanshour Anas, Paria Nandina, Khalid Aysha, Li Yang, Xie Xudong, Feng Jian Q, Xu Qian, Lu Yongbo, Hammer Robert E, Wise Carol A, Beutler Bruce

Abstract excerpt

Proper embryonic and postnatal skeletal development require coordination of myriad complex molecular mechanisms. Disruption of these processes, through genetic mutation, contributes to variation in skeletal development. We developed a high-throughput N-ethyl-N-nitrosourea (ENU)-induced saturation mutagenesis skeletal screening approach in mice to identify genes required for proper skeletal development. Here, we...

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PMID: 33905568
DOI: 10.1002/jbmr.4323
PMCID: PMC8862308

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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